Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens.The formation of a trimeric complex between the HPV E6 oncoprotein, the cellular ubiquitin ligase E6AP and the p53 tumor suppressor protein leads to proteolytic p53 degradation and plays a central role for HPV-induced cell transformation.We here uncover that E6AP silencing
Climate change generates multiple negative impacts for cities, such as the urban heat island effect.Social stresses, including social disadvantage and housing unaffordability, compound the poor living conditions of urban residents and make our cities less resilient.This paper considers a climate event (urban heat) and social stresses (housing affor
We have generated MLi005-A, a new induced pluripotent stem cell (iPSC) line derived from skin fibroblasts of a male patient with dominant dystrophic epidermolysis bullosa (DDEB).This iPSC line may be used MACHETE as a model system for studies on skin integrity, the extracellular matrix and skin barrier function.The characterization of the MLi005-A
This paper presents a novel approach for the joint tracking and identification (JTI) problem.JTI involves interdependent tracking and identification, and thus solving them jointly is preferable.The recently proposed joint decision and estimation (JDE) framework provides a good solution for such problems involving coupled decision and estimation.To